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Image Search Results
Journal: Molecular Psychiatry
Article Title: Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment
doi: 10.1038/s41380-019-0368-6
Figure Lengend Snippet: Aripiprazole (ARI) and its metabolites cross the placental barrier. ARI and its metabolites were readily detectable in the brain of newborn pups. A positive correlation between ARI and dehydroaripiprazole ( a ) and 2,3-dichlorophenylpiperazine ( b ) was observed in the analyzed tissue. Only ARI-treated pup data are disclosed, as in vehicle-treated pup brains no ARI or metabolites were detected. Each symbol denotes ARI level in a single ARI-treated brain sample ( n = 19), filled symbols denote pups with a Dhcr7 +/+ genotype (wild type), open symbols denote pups with a Dhcr7 +/ − genotype. Pearson correlation coefficients ( r 2 and p values) were calculated using GraphPad Prism 7
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